Necrostatin-1 Reduces Neurovascular Injury after Intracerebral Hemorrhage

Necrostatin-1 Reduces Neurovascular Injury after Intracerebral Hemorrhage

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Intracerebral hemorrhage (ICH) is the most common form of hemorrhagic stroke, accounting for 15% of all strokes.ICH has the highest acute mortality and the worst long-term prognosis of all stroke subtypes.Unfortunately, the dearth of clinically effective treatment options makes ICH the least treatable form of Canine - Clothing - Halloween Costumes stroke, emphasizing the need for novel therapeutic targets.Recent work by our laboratory identified a novel role for the necroptosis inhibitor, necrostatin-1, in limiting neurovascular injury in tissue culture models of hemorrhagic injury.In the present study, we tested the hypothesis that necrostatin-1 reduces neurovascular injury after collagenase-induced ICH in mice.

Necrostatin-1 significantly reduced hematoma volume by 54% at 72 Knock Boxes h after-ICH, as compared to either sham-injured mice or mice administered an inactive, structural analogue of necrostatin-1.Necrostatin-1 also limited cell death by 48%, reduced blood-brain barrier opening by 51%, attenuated edema development to sham levels, and improved neurobehavioral outcomes after ICH.These data suggest a potential clinical utility for necrostatin-1 and/or novel necroptosis inhibitors as an adjunct therapy to reduce neurological injury and improve patient outcomes after ICH.